维生素D促进COPD康复
2011-05-30 23:16:04   来源：   作者：  评论：0 点击：

May 27, 2011 (Denver, Colorado) — Patients with chronic obstructive pulmonary disease (COPD) who received high doses of vitamin D supplementation during rehabilitation show significant improvements in respiratory muscle strength and exercise capacity, according to research presented here at the American Thoracic Society 2011 International Conference.
根据发表在美国胸科学协会2011年国际会议的一份研究，患慢性阻塞性肺疾病的患者在康复期接受高剂量的维生素D补充能显著改善呼吸道平滑肌力量与运动耐受程度。

The study was also published in the May issue of the American Journal of Respiratory and Critical Care Medicine.
本研究还发表在《美国呼吸及紧急护理医学》5月刊上。

The improvement in respiratory muscle weakness is a key focus of respiratory rehabilitation for COPD patients, and because low circulating vitamin D levels are commonly associated with muscle weakness, researchers in Belgium theorized that vitamin D supplementation would help with COPD rehabilitation.
改善呼吸道平滑肌肌力是促进COPD患者康复一个重要的研究焦点，因为血浆维生素D含量低通常与肌力低下相关，比利时的研究者由此推论补充维生素D可以促进COPD康复。

"Since muscle weakness, the major target for respiratory rehabilitation, is a common phenomenon in COPD, we explored the additional effect of vitamin D supplementation on rehabilitation," said Miek Hornikx, physiotherapist and doctoral student in the Department of Pneumology at the Katholieke Universiteit Leuven, in Belgium.
比利时鲁汶大学肺病学系物理治疗师、博士研究生Miek Hornikx 介绍说：“由于呼吸道平滑肌肌力低下是COPD常见现象，改善肌力成为促进呼吸道康复的重要目标。我们研究额外维生素D的补充对肌力恢复的作用效果。”

For the study, 50 COPD patients with a history of exacerbations who were referred for rehabilitation were randomly assigned to receive either a monthly dose of 100,000 IU of vitamin D or placebo.
50名病情曾恶化而后又转诊到康复科的COPD患者被随机分配到两个组：维生素D月剂量100000国际单位治疗组、安慰剂对照组。

All subjects participated in a 3-month pulmonary rehabilitation program. At the end of the program, vitamin D levels in the treatment group had increased significantly, compared with the placebo group — from 22.8 ± 15.3 ng/mL at baseline to 53.8 ± 15.6 ng/mL at 3 months.
所有受试者参加了为时3个月的肺功能康复计划。在计划结束时，与安慰剂组相比，治疗组中患者维生素D的水平有显著上升，基线设为22.8 ± 15.3 ng/mL，3个月后上升至53.8 ± 15.6 ng/mL。

Patients receiving vitamin D had significant improvements in nearly all measures of COPD. Compared with patients in the placebo group, those receiving vitamin D showed a larger improvement in maximal oxygen consumption (+0.11 ± 0.21 vs –0.02 ± 0.19 L/min; P = .029).
接受维生素D治疗的患者在几乎所有测量COPD的指标中都有显著的改善。与安慰剂对照组相比，接受维生素D治疗的患者最大氧利用率（？）出现较大的好转（+0.11 ± 0.21 vs –0.02 ± 0.19 L/min; P = .029）。

The vitamin D group also showed improvements in maximal workload (P = .060); 6-minute walking distance (36 ± 55 vs 11 ± 74 m; P = .179); quadriceps force (15 ± 16 vs 6.8 ± 19 Nm; P = .121); inspiratory muscle force (–11 ± 12 vs 0 ± 14 cm H2O; P = .06), expiratory muscle force (P = .376); and Chronic Respiratory Disease Questionnaire score for dyspnea (P = .337).
同时，维生素治疗组最大运动荷载量（？）显示了较大的提升(P = .060)。类似的改善还有：6分钟步行距离(36 ± 55 vs 11 ± 74 m; P = .179)、复合腿部力量（？）(15 ± 16 vs 6.8 ± 19 Nm; P = .121)、吸气肌肌力(–11 ± 12 vs 0 ± 14 cm H2O; P = .06)、呼气肌肌力(P = .376)及慢性呼吸道疾病呼吸困难问卷评分(P = .337)。

A small increase in forced expiratory volume in 1 s was similar in both groups (4.70% ± 17.1% vs 2.61 ± 23.8%; P = .727).
1秒呼气容量在两组均有小幅上升(4.70% ± 17.1% vs 2.61 ± 23.8%; P = .727)。

The findings offer promising evidence that a nonpharmaceutical therapy might help to improve outcomes in pulmonary rehabilitation, noted Richard Casaburi, PhD, MD, director of Clinical Respiratory Physiology Laboratories at Harbor–University of California at Los Angeles (UCLA) Medical Center, in Torrance, California.
加利福尼亚州托兰斯加利福尼亚大学洛杉矶医学研究中心临床呼吸生理实验室主任Richard Casaburi博士评论说，此次研究结果为非药物疗法改善肺功能恢复预后提供了积极的证明。

"We have been seeking pharmacologic options to boost the effectiveness of pulmonary rehabilitation for some time," said Dr. Casaburi, who is also associate chief for research and professor of medicine in Harbor–UCLA Medical Center's division of respiratory and critical care physiology and medicine.
Casaburi 博士是加州大学医研中心呼吸与紧急护理生理及医学系教授，同时是研究中心的副主任。他提到：“我们一直寻找促进肺功能恢复的药物治疗方案，”

"So far, no drugs have been shown to amplify the effects of rehabilitation on exercise endurance," he said. "The trends shown here indicate that vitamin D supplementation is worth pursuing in this context."
“迄今为止，尚未有一个理想的药物可以促进运动耐受的恢复。通过这次的研究，我们看出了非药物治疗的趋势，补充维生素D是一个值得探讨的话题。”

"Although the results are encouraging, the largely nonstatistically significant trends cannot be considered definitive. A larger, adequately powered study would be of great interest," Dr. Casaburi noted.
“尽管结果振奋人心，但这个趋势并未具备统计学显著差异，所以尚且未能下确切的结论。我们期待着未来具有足够说服力（？）的大样本研究。”