母婴传播为儿童感染HCV的原因
2013-09-07 11:25:38   来源：37度医学网   作者：  评论：0 点击：

Mother-to-child transmission is the leadingcauses of hepatitis C virus infection in children, according to recent findingspublished in The Journal of Pediatrics.
根据近期发表在儿科杂志的研究结果显示,母婴传播是儿童感染HCV的首要原因。
“Mother-to-child transmission of HCV isdefined as transmission occurring during pregnancy or in the perinatal periodfrom the HCV-infected mother to the fetus or to the child,” according tobackground information in the study. “The exact timing and the ultimatemechanism of mother-to-child transmission of HCV infection are unknown. Amongchildren acquiring infections from the mother, only a few have been found to beHCV-RNA positive in the first days of life.”
“丙肝的母婴传播的定义是在怀孕期间发生传播或者在围产期有感染丙型肝炎的母亲传染给胎儿或幼儿，”根据研究的背景资料所示。“母婴传播HCV感染的确切时间和最终机制还不清楚，在那些从母亲获得感染的幼儿，仅有少数在生命早期发现HCV-RNA阳性。
Transmission of HCV is more likely to occur if the mothers had ahistory of IV drug use, were coinfected with HIV, and had higher liver diseaseactivity as defined by the presence of elevated aminotransferase levels. Themajor risk factors for perinatal transmission of HCV were shown to be dependenton peripheral blood mononuclear cell (PBMC) infection with HCV.
HCV传播更可能发生于母亲有静脉药瘾病史，合并有HIV感染者和存在转氨酶水平升高的较高的肝病活动性的母亲。围产期丙型肝炎感染的主要危险因素被证明是依赖于外周血中受HCV感染的单核细胞。
“HCV-infected maternal PBMCs can be thecarrier of the virus inside the child, serving as a Trojan horse for HCVentry,” researchers wrote. “Once inside the child, the efficiency oftransmission is dependent on the infection of newborn target cells that in turnis related to the persistence of maternal-infected cells in fetal/neonatalblood.”
“HCV感染的母体单核细胞可作为HCV进入的一个木马，能成为病毒进入儿童体内的运载体，”研究者写到。“一旦进入儿童体内，传播的效率依赖于新生儿受感染的靶细胞，而这又与胎儿/新生儿血中来源于母体的受感染细胞的持续存在相关。”
However, because transmission is notcompletely understood, no effective prevention intervention is currentlyavailable.
然而，因为传播（机制）并没有完全搞清，现今并没有有效的预防干预措施。
”Perinatal transmission of HCV is a complexand almost unexplained phenomenon,” Giuseppe Infoldi, MD, of Meyer Children’s UniversityHospital of Florence, toldInfectiousDiseases in Children. “Further research and attention by cliniciansis needed in the future for the leading route of acquisition of HCV infectionin children.”

“HCV的母婴传播是一个复杂，几乎无法解释的现象，”佛罗伦萨迈耶大学儿童医院的基斯普.尹福德博士在讲述儿童感染性疾病时说道。“在未来，临床医生对这种儿童获得性HCV感染首要途径的深入研究和关注是必需的。”
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编译：485字

母婴传播为儿童感染HCV的原因

根据近期发表在儿科杂志的研究结果显示,母婴传播是儿童感染HCV的首要原因。

“丙肝的母婴传播的定义是在怀孕期间发生传播或者在围产期有感染丙型肝炎的母亲传染给胎儿或幼儿，”根据研究的背景资料所示。“母婴传播HCV感染的确切时间和最终机制还不清楚，在那些从母亲获得感染的幼儿，仅有少数在生命早期发现HCV-RNA阳性。HCV传播更可能发生于母亲有静脉药瘾病史，合并有HIV感染者和存在转氨酶水平升高的较高的肝病活动性的母亲。围产期丙型肝炎感染的主要危险因素被证明是依赖于外周血中受HCV感染的单核细胞。“HCV感染的母体单核细胞可作为HCV进入的一个木马，能成为病毒进入儿童体内的运载体，”研究者写到。“一旦进入儿童体内，传播的效率依赖于新生儿受感染的靶细胞，而这又与胎儿/新生儿血中来源于母体的受感染细胞的持续存在相关。”

然而，因为传播（机制）并没有完全搞清，现今并没有有效的预防干预措施。“HCV的母婴传播是一个复杂，几乎无法解释的现象，”佛罗伦萨迈耶大学儿童医院的基斯普.尹福德博士在讲述儿童感染性疾病时说道。“在未来，临床医生对这种儿童获得性HCV感染首要途径的深入研究和关注是必需的。”