用抗癌药治疗糖尿病在小鼠中喜获成功
2009-05-26 20:36:09 来源： 作者： 评论：0 点击：
用抗癌药治疗糖尿病在小鼠中获得成功
A team of scientists from Plexxikon and UC San Francisco say they were able to eliminate symptoms of Type 1 diabetes in mice by treating them with Gleevec and Sutent, two well known cancer drugs. In a study published in the Proceedings of the National Academy of Sciences, the scientists say they were also able to delay disease progression by giving the genetically modified mice daily treatments of Gleevec.
来自Plexxikon 和美国加州大学旧金山分校的科学家小组称，采用格列卫（伊马替尼）和Sutent（舒尼替尼）（两种常用抗癌药）治疗可以减轻1型糖尿病小鼠的症状。发表在国家科学院院刊上的一项研究中，科学家称通过每日给予转基因小鼠格列卫也可以延缓其糖尿病进程。
Only one in five of the treated mice became progressively diabetic at 30 weeks of age, compared to 71 percent in the untreated group. And the majority of mice remained Type 1-free at 50 weeks, which the researchers point to as a sign that the drugs could have a long-lasting effect.
五只接受治疗的小鼠中仅有一只在30周时逐渐出现糖尿病症状，而对照组的糖尿病发生率为71％。而且大多数小鼠在50周仍未出现1型糖尿病，研究人员认为这说明这些药物有长期效果。
The scientists say that the drugs appeared to work by soothing the animals' over-active immune system, which in turn stopped damaging the pancreas. Type 1 diabetes is caused when inflammation destroys cells in the pancreas. There is currently no known cure for Type 1 diabetes.
科学家称，这些药物的作用机制可能是通过缓解动物免疫系统过激，进而阻止对胰腺的损伤。而当炎症损伤胰腺细胞后即导致1型糖尿病。目前尚无治疗1型糖尿病的方法。
A team of scientists from Plexxikon and UC San Francisco say they were able to eliminate symptoms of Type 1 diabetes in mice by treating them with Gleevec and Sutent, two well known cancer drugs. In a study published in the Proceedings of the National Academy of Sciences, the scientists say they were also able to delay disease progression by giving the genetically modified mice daily treatments of Gleevec.
来自Plexxikon 和美国加州大学旧金山分校的科学家小组称，采用格列卫（伊马替尼）和Sutent（舒尼替尼）（两种常用抗癌药）治疗可以减轻1型糖尿病小鼠的症状。发表在国家科学院院刊上的一项研究中，科学家称通过每日给予转基因小鼠格列卫也可以延缓其糖尿病进程。
Only one in five of the treated mice became progressively diabetic at 30 weeks of age, compared to 71 percent in the untreated group. And the majority of mice remained Type 1-free at 50 weeks, which the researchers point to as a sign that the drugs could have a long-lasting effect.
五只接受治疗的小鼠中仅有一只在30周时逐渐出现糖尿病症状，而对照组的糖尿病发生率为71％。而且大多数小鼠在50周仍未出现1型糖尿病，研究人员认为这说明这些药物有长期效果。
The scientists say that the drugs appeared to work by soothing the animals' over-active immune system, which in turn stopped damaging the pancreas. Type 1 diabetes is caused when inflammation destroys cells in the pancreas. There is currently no known cure for Type 1 diabetes.
科学家称，这些药物的作用机制可能是通过缓解动物免疫系统过激，进而阻止对胰腺的损伤。而当炎症损伤胰腺细胞后即导致1型糖尿病。目前尚无治疗1型糖尿病的方法。
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