胸水DNA可能提供恶性胸腔积液证据
2009-05-26 20:36:09 来源： 作者： 评论：0 点击：
Pleural Fluid DNA May Yield Evidence of Malignant Pleural Effusion
. 胸水DNA可能提供恶性胸腔积液证据
NEW YORK (Reuters Health) May 08 - Pleural fluid DNA showing hypermethylation of a number of tumor suppressor genes is associated with malignant pleural effusion, according to findings from a Japanese study published in the May 15th issue of the International Journal of Cancer.
（纽约路透电） 08 年5月-一项 5月1 5日发表在国际癌症期刊的日本的研究发现，胸水DNA检查显示一些肿瘤抑制基因的超甲基化与恶性胸腔积液相关。
Dr. Hideki Katayama at NHO Sanyo National Hospital in Yamaguchi, Japan, and colleagues tested pleural fluid from 47 patients with malignant effusions and 34 patients with nonmalignant effusions for evidence of DNA hypermethylation in five tumor suppressor genes.
日本山口NHO三洋国立医院的Dr. Hideki Katayama，和他的同事检测了47例恶性胸腔积液和34例非恶性胸腔积液证明五个抑癌基因存在DNA超甲基化。
Patients with hypermethylation of four of the five tumor suppressor genes (MGMT, p16-INK4a, RASSFIA, and RAR-beta) were 5.68-times more likely to have malignant effusions than those without hypermethylation, the investigators report.
研究者报告，如有5个肿瘤抑制基因中的4个发生超甲基化（MGMT，， p16-INK4a ， RASSFIA ，和RAR - β ）患者有恶性胸腔积液可能性比未超甲基化的高5.68倍。
Hypermethylation in the fifth oncogene, DAPK, was not associated with malignant effusion but was associated with length of time smoking.
发生超甲基化的第五个基因 DAPK 与恶性胸水无关，但和吸烟时间长短的有关。
"Sensitivity, specificity and positive predictive power of methylation in one or more genes for diagnosis of malignant effusion were 59.6%, 79.4% and 80.0%, respectively," the researchers report.
研究者报告，“甲基化在一个或多个基因诊断恶性胸水的的敏感性，特异性和阳性预测力分别是59.6 ％ ， 79.4 ％和80.0 ％ ”。
They conclude that "aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could be a valuable diagnostic marker for malignant pleural effusion."
他们总结说， “胸腔积液DNA检查发现抑癌基因的启动子异常甲基化的可以作为诊断恶性胸腔积液标志。
Int J Cancer 2007;120:2191-2195.
国际癌症2007 ; 120:2191-2195 。
. 胸水DNA可能提供恶性胸腔积液证据
NEW YORK (Reuters Health) May 08 - Pleural fluid DNA showing hypermethylation of a number of tumor suppressor genes is associated with malignant pleural effusion, according to findings from a Japanese study published in the May 15th issue of the International Journal of Cancer.
（纽约路透电） 08 年5月-一项 5月1 5日发表在国际癌症期刊的日本的研究发现，胸水DNA检查显示一些肿瘤抑制基因的超甲基化与恶性胸腔积液相关。
Dr. Hideki Katayama at NHO Sanyo National Hospital in Yamaguchi, Japan, and colleagues tested pleural fluid from 47 patients with malignant effusions and 34 patients with nonmalignant effusions for evidence of DNA hypermethylation in five tumor suppressor genes.
日本山口NHO三洋国立医院的Dr. Hideki Katayama，和他的同事检测了47例恶性胸腔积液和34例非恶性胸腔积液证明五个抑癌基因存在DNA超甲基化。
Patients with hypermethylation of four of the five tumor suppressor genes (MGMT, p16-INK4a, RASSFIA, and RAR-beta) were 5.68-times more likely to have malignant effusions than those without hypermethylation, the investigators report.
研究者报告，如有5个肿瘤抑制基因中的4个发生超甲基化（MGMT，， p16-INK4a ， RASSFIA ，和RAR - β ）患者有恶性胸腔积液可能性比未超甲基化的高5.68倍。
Hypermethylation in the fifth oncogene, DAPK, was not associated with malignant effusion but was associated with length of time smoking.
发生超甲基化的第五个基因 DAPK 与恶性胸水无关，但和吸烟时间长短的有关。
"Sensitivity, specificity and positive predictive power of methylation in one or more genes for diagnosis of malignant effusion were 59.6%, 79.4% and 80.0%, respectively," the researchers report.
研究者报告，“甲基化在一个或多个基因诊断恶性胸水的的敏感性，特异性和阳性预测力分别是59.6 ％ ， 79.4 ％和80.0 ％ ”。
They conclude that "aberrant promoter methylation of tumor suppressor genes in pleural fluid DNA could be a valuable diagnostic marker for malignant pleural effusion."
他们总结说， “胸腔积液DNA检查发现抑癌基因的启动子异常甲基化的可以作为诊断恶性胸腔积液标志。
Int J Cancer 2007;120:2191-2195.
国际癌症2007 ; 120:2191-2195 。
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